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Dr Mark Williams

Lecturer in Biophysics
Director, ISMB Biophysics Centre

Contact details

tel: 020 7079 0659

Research website

About Dr Mark Williams


  • Reasearch in my group aims to understand protein structure-function relationships in basic cellular processes and disease states. Through a multi-disciplinary approach, using biophysical and structural experimental methods, structural bioinformatic analysis and physics-based molecular simulation, we aim to develop as complete as possible an understanding of the formation of biomolecular complexes. We aim to ulitise this knowledge to combat disease via structure-based drug discovery and design, particularly in the area of anti-microbial therapy.

Recent publications

  • Book

    Protein-ligand interactions: Methods and applications 2nd ed., Springer, New York, 2013 Mark A. Williams & Tina Daviter (editors)


    Romain A. Studer, Pascal-Antoine Christin, Mark A. Williams and Christine A. Orengo (2014). Stability-activity trade-offs constrain the adaptive evolution of RubisCO. Proc. Natl. Acad. Sci. USA 111,2223-2228.

    Mark A. Williams (2013). Protein-ligand interactions: Fundamentals. Methods in Molecular Biology 1008, 3-34.

    Paul Ashford, David S. Moss, Alexander Alex, Siew K. Yeap, Alice Povia, Irene Nobeli and Mark A. Williams (2012). Visualization of variable binding pockets on protein surfaces by probabilistic analysis of related structure sets. BMC Bioinformatics 13, 39.

    Tjelvar S.G. Olsson, John E. Ladbury, William R. Pitt and Mark A. Williams (2011). The extent of enthalpy-entropy compensation in protein-ligand interactions. Protein Science 20,1607-1618.

    Paula C.A. da Fonseca, Eric H. Kong, Ziguo Zhang, Anne Schreiber, Mark A. Williams, Edward P. Morris and David Barford (2011). Structures of APC/C-CDH1 with substrates identify Cdh1 and Apc10 as the D-box co-receptor. Nature 470, 274-278..

    Mark J. Edwards, Mark A. Williams, Antony J. Maxwell and Adam McKay (2011). Mass spectrometry reveals that the antibiotic simocyclinone D8 binds to DNA gyrase in a "bent-over" conformation: evidence for positive cooperativity in binding. Biochemistry 50, 3432-3440..

    Brian Henderson, Sean Nair, Jacky Pallas and Mark A. Williams (2011). Fibronectin: a multidomain host adhesin targeted by bacterial fibronectin-binding proteins. FEMS Microbiology Reviews 35, 147-200.

    Sanjay Nilapwar, Eleanor P. Smith, Christopher Fu, Christomos Prodromou, Laurence H. Pearl, Mark A. Williams and John E. Ladbury (2009). Structural-thermodynamics relationships of interactions in the N-terminal ATP binding domain of Hsp90. J. Mol. Biol. 392, 923-936..


  • I teach on the following MSc/MRes programmes in Bioinformatics with Systems Biology and Structural Molecular Biology modules:
    • Molecular Structure - molecular visualization
    • Structural Bioinformatics - analysis of protein structures, protein physics, and structure-based drug design (module organiser)
    • Statistics - non-parametric methods, category analysis, and data modelling
    • Techniques in Structural Molecular Biology - protein biophysics and measurement of interactions
    I also contribute some lectures on protein NMR and protein engineering to the Graduate Studies Programme and BSc programmes.
    I am Birkbeck's Coordinator for the BBSRC sponsored London Interdisciplinary Doctoral Programme (LIDo)

Dr Mark Williams